Little Black Mushroomcloud

The fungus among us...nope,just chelsita.

Southeast Asia

(Source: spacecakeofawesome, via austro-nesian)

neurosciencestuff:

Chrono, the last piece of the circadian clock puzzle?
In an article published today in PLOS Biology, researchers from the RIKEN Brain Science Institute in Japan report the identification of Chrono, a gene involved in the regulation of the body clock in mammals and that might be a key component of the body’s response to stress.

All organisms, from mammals to fungi, have daily cycles controlled by a tightly regulated internal clock, called the circadian clock. The whole-body circadian clock, influenced by the exposure to light, dictates the wake-sleep cycle. At the cellular level, the clock is controlled by a complex network of genes and proteins that switch each other on and off based on cues from their environment.
Most genes involved in the regulation of the circadian clock have been characterized, but Akihiro Goriki, Toru Takumi and their colleagues from RIKEN and Hiroshima University in Japan and University of Michigan in the United States knew that a key component was missing and sough to uncover it in mammals.
In the study, the team performed a genome-wide chromatin immunoprecipitation analysis for genes that were the target of BMAL1, a core clock component that binds to many other clock genes, regulating their transcription.
The authors characterize a new circadian gene that they name Chrono. They show that CHRONO functions as a transcriptional repressor of the negative feedback loop in the mammalian clock: the protein CHRONO binds to the regulatory region of clock genes, with its repressor function oscillating in a circadian manner. The expression of core clock genes is altered in mice lacking the Chrono gene, and the mice have longer circadian cycles.
"These results suggest that Chrono functions as a core clock repressor,” conclude the authors.
In addition, they demonstrate that the repression mechanism of Chrono is under epigenetic control and links, via a glucocorticoid receptor, to metabolic pathways triggered by behavioral stress.
These findings are confirmed by another study by the University of Pennsylvania, also published in PLOS Biology today. In the study, John Hogenesch and his team prove the existence of Chrono using a computer-based analysis.

neurosciencestuff:

Chrono, the last piece of the circadian clock puzzle?

In an article published today in PLOS Biology, researchers from the RIKEN Brain Science Institute in Japan report the identification of Chrono, a gene involved in the regulation of the body clock in mammals and that might be a key component of the body’s response to stress.

All organisms, from mammals to fungi, have daily cycles controlled by a tightly regulated internal clock, called the circadian clock. The whole-body circadian clock, influenced by the exposure to light, dictates the wake-sleep cycle. At the cellular level, the clock is controlled by a complex network of genes and proteins that switch each other on and off based on cues from their environment.

Most genes involved in the regulation of the circadian clock have been characterized, but Akihiro Goriki, Toru Takumi and their colleagues from RIKEN and Hiroshima University in Japan and University of Michigan in the United States knew that a key component was missing and sough to uncover it in mammals.

In the study, the team performed a genome-wide chromatin immunoprecipitation analysis for genes that were the target of BMAL1, a core clock component that binds to many other clock genes, regulating their transcription.

The authors characterize a new circadian gene that they name Chrono. They show that CHRONO functions as a transcriptional repressor of the negative feedback loop in the mammalian clock: the protein CHRONO binds to the regulatory region of clock genes, with its repressor function oscillating in a circadian manner. The expression of core clock genes is altered in mice lacking the Chrono gene, and the mice have longer circadian cycles.

"These results suggest that Chrono functions as a core clock repressor,” conclude the authors.

In addition, they demonstrate that the repression mechanism of Chrono is under epigenetic control and links, via a glucocorticoid receptor, to metabolic pathways triggered by behavioral stress.

These findings are confirmed by another study by the University of Pennsylvania, also published in PLOS Biology today. In the study, John Hogenesch and his team prove the existence of Chrono using a computer-based analysis.

hoodethicist:

Shit is fucking sickening

hoodethicist:

Shit is fucking sickening

(Source: energy53, via guiltyby--design)

Photo of Anna May Wong with her sister Lew Ying ("Lulu") in 1928

(Source: galleries.apps.chicagotribune.com, via classicladiesofcolor)

7 hours ago - 8

whatisthat-velvet:

dynastylnoire:

brispyedges:

An Archetype.

white tumblr

Literally.

(Source: bellecs, via aztec-princesss)

salviprince:

wifigirl2080:

the-treble:

thepeoplesrecord:

The 1% wants to ban sleeping in cars - it hurts their ‘quality of life’April 16, 2014
Across the United States, many local governments are responding to skyrocketing levels of inequality and the now decades-long crisis of homelessness among the very poor … by passing laws making it a crime to sleep in a parked car.
This happened most recently in Palo Alto, in California’s Silicon Valley, where new billionaires are seemingly minted every month – and where 92% of homeless people lack shelter of any kind. Dozens of cities have passed similar anti-homeless laws. The largest of them is Los Angeles, the longtime unofficial “homeless capital of America”, where lawyers are currently defending a similar vehicle-sleeping law before a skeptical federal appellate court. Laws against sleeping on sidewalks or in cars are called “quality of life” laws. But they certainly don’t protect the quality of life of the poor.
To be sure, people living in cars cannot be the best neighbors. Some people are able to acquire old and ugly – but still functioning – recreational vehicles with bathrooms; others do the best they can. These same cities have resisted efforts to provide more public toilet facilities, often on the grounds that this will make their city a “magnet” for homeless people from other cities. As a result, anti-homeless ordinances often spread to adjacent cities, leaving entire regions without public facilities of any kind.
Their hope, of course, is that homeless people will go elsewhere, despite the fact that the great majority of homeless people are trying to survive in the same communities in which they were last housed – and where they still maintain connections. Americans sleeping in their own cars literally have nowhere to go.
Indeed, nearly all homelessness in the US begins with a loss of income and an eviction for nonpayment of rent – a rent set entirely by market forces. The waiting lists are years long for the tiny fraction of housing with government subsidies. And rents have risen dramatically in the past two years, in part because long-time tenants must now compete with the millions of former homeowners who lost their homes in the Great Recession.
The paths from eviction to homelessness follow familiar patterns. For the completely destitute without family or friends able to help, that path leads more or less directly to the streets. For those slightly better off, unemployment and the exhaustion of meager savings – along with the good graces of family and friends – eventually leaves people with only two alternatives: a shelter cot or their old automobile.
However, in places like Los Angeles, the shelters are pretty much always full. Between 2011 and 2013, the number of unsheltered homeless people increased by 67%. In Palo Alto last year, there were 12 shelter beds for 157 homeless individuals. Homeless people in these cities do have choices: they can choose to sleep in a doorway, on a sidewalk, in a park, under a bridge or overpass, or – if they are relatively lucky – in a car. But these cities have ordinances that make all of those choices a criminal offense. The car is the best of bad options, now common enough that local bureaucrats have devised a new, if oxymoronic, term – the “vehicularly housed”.
People sleeping in cars try to find legal, nighttime parking places, where they will be less apparent and arouse the least hostility. But cities like Palo Alto and Los Angeles often forbid parking between 2am and 5am in commercial areas, where police write expensive tickets and arrest and impound the vehicles of repeat offenders. That leaves residential areas, where overnight street parking cannot, as a practical matter, be prohibited.
One finds the “vehicularly housed” in virtually every neighborhood, including my own. But the animus that drives anti-homeless laws seems to be greatest in the wealthiest cities, like Palo Alto, which has probably spawned more per-capita fortunes than any city on Earth, and in the more recently gentrified areas like Los Angeles’ Venice. These places are ruled by majorities of “liberals” who decry, with increasing fervor, the rapid rise in economic inequality. Nationally, 90% of Democrats (and 45% of Republicans) believe the government should act to reduce the rich-poor gap.
It is easy to be opposed to inequality in the abstract. So why are Los Angeles and Palo Alto spending virtually none of their budgets on efforts to provide housing for the very poor and homeless? When the most obvious evidence of inequality parks on their street, it appears, even liberals would rather just call the police. The word from the car: if you’re not going to do anything to help, please don’t make things worse.
Source

Wait it’s illegal to sleep in your car in Palo Alto?
Well, I’ve been breakin’ the law.

Kill the wealthy.
No like all of them.

These palo alto people, with their tech companies are gentrifying and are pushing people to literally live in cars but won’t even let them do that.

salviprince:

wifigirl2080:

the-treble:

thepeoplesrecord:

The 1% wants to ban sleeping in cars - it hurts their ‘quality of life’
April 16, 2014

Across the United States, many local governments are responding to skyrocketing levels of inequality and the now decades-long crisis of homelessness among the very poor … by passing laws making it a crime to sleep in a parked car.

This happened most recently in Palo Alto, in California’s Silicon Valley, where new billionaires are seemingly minted every month – and where 92% of homeless people lack shelter of any kind. Dozens of cities have passed similar anti-homeless laws. The largest of them is Los Angeles, the longtime unofficial “homeless capital of America”, where lawyers are currently defending a similar vehicle-sleeping law before a skeptical federal appellate court. Laws against sleeping on sidewalks or in cars are called “quality of life” laws. But they certainly don’t protect the quality of life of the poor.

To be sure, people living in cars cannot be the best neighbors. Some people are able to acquire old and ugly – but still functioning – recreational vehicles with bathrooms; others do the best they can. These same cities have resisted efforts to provide more public toilet facilities, often on the grounds that this will make their city a “magnet” for homeless people from other cities. As a result, anti-homeless ordinances often spread to adjacent cities, leaving entire regions without public facilities of any kind.

Their hope, of course, is that homeless people will go elsewhere, despite the fact that the great majority of homeless people are trying to survive in the same communities in which they were last housed – and where they still maintain connections. Americans sleeping in their own cars literally have nowhere to go.

Indeed, nearly all homelessness in the US begins with a loss of income and an eviction for nonpayment of rent – a rent set entirely by market forces. The waiting lists are years long for the tiny fraction of housing with government subsidies. And rents have risen dramatically in the past two years, in part because long-time tenants must now compete with the millions of former homeowners who lost their homes in the Great Recession.

The paths from eviction to homelessness follow familiar patterns. For the completely destitute without family or friends able to help, that path leads more or less directly to the streets. For those slightly better off, unemployment and the exhaustion of meager savings – along with the good graces of family and friends – eventually leaves people with only two alternatives: a shelter cot or their old automobile.

However, in places like Los Angeles, the shelters are pretty much always full. Between 2011 and 2013, the number of unsheltered homeless people increased by 67%. In Palo Alto last year, there were 12 shelter beds for 157 homeless individuals. Homeless people in these cities do have choices: they can choose to sleep in a doorway, on a sidewalk, in a park, under a bridge or overpass, or – if they are relatively lucky – in a car. But these cities have ordinances that make all of those choices a criminal offense. The car is the best of bad options, now common enough that local bureaucrats have devised a new, if oxymoronic, term – the “vehicularly housed”.

People sleeping in cars try to find legal, nighttime parking places, where they will be less apparent and arouse the least hostility. But cities like Palo Alto and Los Angeles often forbid parking between 2am and 5am in commercial areas, where police write expensive tickets and arrest and impound the vehicles of repeat offenders. That leaves residential areas, where overnight street parking cannot, as a practical matter, be prohibited.

One finds the “vehicularly housed” in virtually every neighborhood, including my own. But the animus that drives anti-homeless laws seems to be greatest in the wealthiest cities, like Palo Alto, which has probably spawned more per-capita fortunes than any city on Earth, and in the more recently gentrified areas like Los Angeles’ Venice. These places are ruled by majorities of “liberals” who decry, with increasing fervor, the rapid rise in economic inequality. Nationally, 90% of Democrats (and 45% of Republicans) believe the government should act to reduce the rich-poor gap.

It is easy to be opposed to inequality in the abstract. So why are Los Angeles and Palo Alto spending virtually none of their budgets on efforts to provide housing for the very poor and homeless? When the most obvious evidence of inequality parks on their street, it appears, even liberals would rather just call the police. The word from the car: if you’re not going to do anything to help, please don’t make things worse.

Source

Wait it’s illegal to sleep in your car in Palo Alto?

Well, I’ve been breakin’ the law.

Kill the wealthy.

No like all of them.

These palo alto people, with their tech companies are gentrifying and are pushing people to literally live in cars but won’t even let them do that.

(via putamarimachajota)

Comedy Central: Give Daily Show Correspondent Jessica Williams her own show now that the Colbert Report is ending

centersfordiseasecontrol:

seriouslyamerica:

PETITION FOR THE HILARIOUS JESSICA WILLIAMS TO GET HER OWN SHOW!

image

image

image

YES YES YES YES YES 

(via actressesofcolor)

1 day ago - 5748
lastrealindians:

From protesters near Tyendinaga.

lastrealindians:

From protesters near Tyendinaga.

(via reclaimingthenativetag)

fallopianrhapsody:

International words for “Strap On”

fallopianrhapsody:

International words for “Strap On”

(via fetus-teeth)